The interplay of frontier research in neutrino physics, nucleosynthesis, abundance observations, and high- performance computing lies at the heart of efforts to understand core collapse supernovae, compact object mergers, and the mass assembly history of galaxies. New observations are driving exciting new developments in these fields. This school will provide the background for addressing these issues, including use of several of the relevant computer codes. The school will be hosted at the SDSC, whose data-intensive computing facilities, including the Gordon supercomputer with a third of a petabyte of flash storage, are among the best in the world. All students at ISSAC 2014 will have accounts on Gordon, and will participate in hands-on code sessions in the afternoons with lectures in the mornings.